The Influenza Centre"> pub2015
PUBLICATIONS 2015 -


Trieu MC, Zhou F, Lartey SL, Sridhar S, Mjaaland S, Cox RJ. Augmented CD4(+)
T-cell and humoral responses after repeated annual influenza vaccination with the
same vaccine component A/H1N1pdm09 over 5 years. NPJ Vaccines. 2018 Aug 14;3:37.
doi: 10.1038/s41541-018-0069-1. eCollection 2018. PubMed PMID: 30131880; PubMed
Central PMCID: PMC6092382.


Trombetta CM, Ulivieri C, Cox RJ, Remarque EJ, Centi C, Perini D, Piccini G,
Rossi S, Marchi S, Montomoli E. Impact of erythrocyte species on assays for
influenza serology. J Prev Med Hyg. 2018 Mar 30;59(1):E1-E7. doi:
10.15167/2421-4248/jpmh2018.59.1.870. eCollection 2018 Mar. PubMed PMID:
29938233; PubMed Central PMCID: PMC6009068.


Trieu MC, Jul-Larsen Å, Sævik M, Madsen A, Nøstbakken JK, Zhou F, Skrede S,
Cox RJ. Antibody responses to influenza A/H1N1pdm09 virus after pandemic and
seasonal influenza vaccination in healthcare workers: a five-year follow-up
study. Clin Infect Dis. 2018 Jun 9. doi: 10.1093/cid/ciy487. [Epub ahead of
print] PubMed PMID: 29893797.


Brokstad KA, Fredriksen M, Zhou F, Bergum B, Brun JG, Cox RJ, Skarstein K. T
follicular-like helper cells in the peripheral blood of patients with primary
Sjögren's syndrome. Scand J Immunol. 2018 Jun 8:e12679. doi: 10.1111/sji.12679.
[Epub ahead of print] PubMed PMID: 29882349.


Mohn KG, Zhou F. Clinical Expectations for Better Influenza Virus
Vaccines-Perspectives from the Young Investigators' Point of View. Vaccines
(Basel). 2018 May 26;6(2). pii: E32. doi: 10.3390/vaccines6020032. Review. PubMed
PMID: 29861454; PubMed Central PMCID: PMC6027204.


Zhou F, Trieu MC, Davies R, Cox RJ. Improving influenza vaccines: challenges
to effective implementation. Curr Opin Immunol. 2018 Apr 29;53:88-95. doi:
10.1016/j.coi.2018.04.010. [Epub ahead of print] Review. PubMed PMID: 29719276.


Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L,
Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K,
Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U,
Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ,
Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A,
Kainov D. Novel activities of safe-in-human broad-spectrum antiviral agents.
Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub
2018 Apr 23. PubMed PMID: 29698664.


Tete SM, Jul-Larsen Å, Rostami S, Lunde THF, Søland H, Krammer F, Cox RJ.
Impact of pre-existing immunity on the induction of functional cross-reactive
anti-hemagglutinin stalk antibodies following vaccination with an AS03 adjuvanted
pandemic H1N1 vaccine. Vaccine. 2018 Apr 12;36(16):2213-2219. doi:
10.1016/j.vaccine.2018.02.022. Epub 2018 Mar 13. PubMed PMID: 29548607.


Olberg HK, Eide GE, Cox RJ, Jul-Larsen Å, Lartey SL, Vedeler CA, Myhr KM.
Antibody response to seasonal influenza vaccination in patients with multiple
sclerosis receiving immunomodulatory therapy. Eur J Neurol. 2018
Mar;25(3):527-534. doi: 10.1111/ene.13537. Epub 2018 Jan 6. PubMed PMID:
29205701.


Savic M, Dembinski JL, Laake I, Hungnes O, Cox R, Oftung F, Trogstad L,
Mjaaland S. Distinct T and NK cell populations may serve as immune correlates of
protection against symptomatic pandemic influenza A(H1N1) virus infection during
pregnancy. PLoS One. 2017 Nov 16;12(11):e0188055. doi:
10.1371/journal.pone.0188055. eCollection 2017. PubMed PMID: 29145441; PubMed
Central PMCID: PMC5690673.


Ebensen T, Debarry J, Pedersen GK, Blazejewska P, Weissmann S, Schulze K,
McCullough KC, Cox RJ, Guzmán CA. Mucosal Administration of
Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against
Influenza H5N1 in Mice. Front Immunol. 2017 Sep 28;8:1223. doi:
10.3389/fimmu.2017.01223. eCollection 2017. PubMed PMID: 29033942; PubMed Central
PMCID: PMC5624999.


Mohn KG, Smith I, Sjursen H, Cox RJ. Immune responses after live attenuated
influenza vaccination. Hum Vaccin Immunother. 2018 Mar 4;14(3):571-578. doi:
10.1080/21645515.2017.1377376. Epub 2018 Jan 3. PubMed PMID: 28933664; PubMed
Central PMCID: PMC5861782.


Andersen TK, Zhou F, Cox R, Bogen B, Grødeland G. A DNA Vaccine That Targets
Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza. J
Virol. 2017 Nov 14;91(23). pii: e01340-17. doi: 10.1128/JVI.01340-17. Print 2017
Dec 1. PubMed PMID: 28931687; PubMed Central PMCID: PMC5686743.


Jacobsen H, Rajendran M, Choi A, Sjursen H, Brokstad KA, Cox RJ, Palese P,
Krammer F, Nachbagauer R. Influenza Virus Hemagglutinin Stalk-Specific Antibodies
in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer
Mouse Challenge Model. MBio. 2017 Sep 19;8(5). pii: e01463-17. doi:
10.1128/mBio.01463-17. PubMed PMID: 28928215; PubMed Central PMCID: PMC5605943.


Islam S, Mohn KG, Krammer F, Sanne M, Bredholt G, Jul-Larsen Å, Tete SM, Zhou
F, Brokstad KA, Cox RJ. Influenza A haemagglutinin specific IgG responses in
children and adults after seasonal trivalent live attenuated influenza
vaccination. Vaccine. 2017 Oct 9;35(42):5666-5673. doi:
10.1016/j.vaccine.2017.08.044. Epub 2017 Sep 9. PubMed PMID: 28899626.


Brauner S, Folkersen L, Kvarnström M, Meisgen S, Petersen S, Franzén-Malmros
M, Mofors J, Brokstad KA, Klareskog L, Jonsson R, Westerberg LS, Trollmo C,
Malmström V, Ambrosi A, Kuchroo VK, Nordmark G, Wahren-Herlenius M. H1N1
vaccination in Sjögren's syndrome triggers polyclonal B cell activation and
promotes autoantibody production. Ann Rheum Dis. 2017 Oct;76(10):1755-1763. doi:
10.1136/annrheumdis-2016-210509. Epub 2017 Jul 31. PubMed PMID: 28760805; PubMed
Central PMCID: PMC5629946.


Dembinski JL, Mihret A, Yimer SA, Tessema B, Trieu MC, Tarekegn A, Getachew
N, Cox RJ, Oftung F, Haneberg B, Aseffa A, Mjaaland S. High Prevalence of Humoral
and Cellular Immunity to Influenza Viruses in Preschool Children Living in Addis
Ababa, Ethiopia. Open Forum Infect Dis. 2017 Feb 11;4(1):ofx026. doi:
10.1093/ofid/ofx026. eCollection 2017 Winter. PubMed PMID: 28480294; PubMed
Central PMCID: PMC5414001.


Mohn KGI, Zhou F, Brokstad KA, Sridhar S, Cox RJ. Boosting of Cross-Reactive
and Protection-Associated T Cells in Children After Live Attenuated Influenza
Vaccination. J Infect Dis. 2017 May 15;215(10):1527-1535. doi:
10.1093/infdis/jix165. PubMed PMID: 28368530; PubMed Central PMCID: PMC5461427.


Trieu MC, Zhou F, Lartey S, Jul-Larsen Å, Mjaaland S, Sridhar S, Cox RJ.
Long-term Maintenance of the Influenza-Specific Cross-Reactive Memory CD4+ T-Cell
Responses Following Repeated Annual Influenza Vaccination. J Infect Dis. 2017 Mar
1;215(5):740-749. doi: 10.1093/infdis/jiw619. PubMed PMID: 28007925.


Manenti A, Tete SM, Mohn KG, Jul-Larsen Å, Gianchecchi E, Montomoli E,
Brokstad KA, Cox RJ. Comparative analysis of influenza A(H3N2) virus
hemagglutinin specific IgG subclass and IgA responses in children and adults
after influenza vaccination. Vaccine. 2017 Jan 3;35(1):191-198. doi:
10.1016/j.vaccine.2016.10.024. Epub 2016 Oct 24. PubMed PMID: 27789145.


Voltersvik P, Aqrawi LA, Dudman S, Hungnes O; Norwegian Lung Pathology Group,
Bostad L, Brokstad KA, Cox RJ. Pulmonary changes in Norwegian fatal cases of
pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic
study. Influenza Other Respir Viruses. 2016 Nov;10(6):525-531. doi:
10.1111/irv.12410. Epub 2016 Sep 1. PubMed PMID: 27413002; PubMed Central PMCID:
PMC5059952.


Mohn KG, Brokstad KA, Pathirana RD, Bredholt G, Jul-Larsen Å, Trieu MC,
Lartey SL, Montomoli E, Tøndel C, Aarstad HJ, Cox RJ. Live Attenuated Influenza
Vaccine in Children Induces B-Cell Responses in Tonsils. J Infect Dis. 2016 Sep
1;214(5):722-31. doi: 10.1093/infdis/jiw230. Epub 2016 May 30. Erratum in: J
Infect Dis. 2016 Oct 3;:. PubMed PMID: 27247344; PubMed Central PMCID:
PMC4978372.


Héquet D, Pascual M, Lartey S, Pathirana RD, Bredholt G, Hoschler K, Hullin
R, Meylan P, Cox RJ, Manuel O. Humoral, T-cell and B-cell immune responses to
seasonal influenza vaccine in solid organ transplant recipients receiving anti-T
cell therapies. Vaccine. 2016 Jun 30;34(31):3576-83. doi:
10.1016/j.vaccine.2016.05.021. Epub 2016 May 21. PubMed PMID: 27219339.


Eagan TM, Hardie JA, Jul-Larsen Å, Grydeland TB, Bakke PS, Cox RJ.
Self-reported influenza vaccination and protective serum antibody titers in a
cohort of COPD patients. Respir Med. 2016 Jun;115:53-9. doi:
10.1016/j.rmed.2016.04.008. Epub 2016 Apr 20. PubMed PMID: 27215504.


Koch AM, Nilsen RM, Eriksen HM, Cox RJ, Harthug S. Mortality related to
hospital-associated infections in a tertiary hospital; repeated cross-sectional
studies between 2004-2011. Antimicrob Resist Infect Control. 2015 Dec 29;4:57.
doi: 10.1186/s13756-015-0097-9. eCollection 2015. PubMed PMID: 26719795; PubMed
Central PMCID: PMC4696323.


Tete SM, Krammer F, Lartey S, Bredholt G, Wood J, Skrede S, Cox RJ.
Dissecting the hemagglutinin head and stalk-specific IgG antibody response in
healthcare workers following pandemic H1N1 vaccination. NPJ Vaccines. 2016;1.
pii: 16001. doi: 10.1038/npjvaccines.2016.1. Epub 2016 Jul 28. PubMed PMID:
29250435; PubMed Central PMCID: PMC5707877.


Mohn KG, Cox RJ, Tunheim G, Berdal JE, Hauge AG, Jul-Larsen Å; Norwegian
Pandemic Group, Peters B, Oftung F, Jonassen CM, Mjaaland S. Immune Responses in
Acute and Convalescent Patients with Mild, Moderate and Severe Disease during the
2009 Influenza Pandemic in Norway. PLoS One. 2015 Nov 25;10(11):e0143281. doi:
10.1371/journal.pone.0143281. eCollection 2015. PubMed PMID: 26606759; PubMed
Central PMCID: PMC4659565.


Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Lim WS, Al Mamun A,
Anovadiya AP, Araújo WN, Azziz-Baumgartner E, Báez C, Bantar C, Barhoush MM,
Bassetti M, Beovic B, Bingisser R, Bonmarin I, Borja-Aburto VH, Cao B, Carratala
J, Cuezzo MR, Denholm JT, Dominguez SR, Duarte PA, Dubnov-Raz G, Echavarria M,
Fanella S, Fraser J, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J,
Higuera Iglesias AL, Hoeger PH, Hoffmann M, Hu X, Islam QT, Jiménez MF, Kandeel
A, Keijzers G, Khalili H, Khandaker G, Knight M, Kusznierz G, Kuzman I, Kwan AM,
Lahlou Amine I, Langenegger E, Lankarani KB, Leo YS, Linko R, Liu P, Madanat F,
Manabe T, Mayo-Montero E, McGeer A, Memish ZA, Metan G, Mikić D, Mohn KG, Moradi
A, Nymadawa P, Ozbay B, Ozkan M, Parekh D, Paul M, Poeppl W, Polack FP, Rath BA,
Rodríguez AH, Siqueira MM, Skręt-Magierło J, Talarek E, Tang JW, Torres A, Törün
SH, Tran D, Uyeki TM, van Zwol A, Vaudry W, Velyvyte D, Vidmar T, Zarogoulidis P;
PRIDE Consortium Investigators, Nguyen-Van-Tam JS. Impact of neuraminidase
inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant
data meta-analysis. Influenza Other Respir Viruses. 2016 May;10(3):192-204. doi:
10.1111/irv.12363. Epub 2016 Feb 1. PubMed PMID: 26602067; PubMed Central PMCID:
PMC4814862.


Savic M, Dembinski JL, Kim Y, Tunheim G, Cox RJ, Oftung F, Peters B, Mjaaland
S. Epitope specific T-cell responses against influenza A in a healthy population.
Immunology. 2016 Feb;147(2):165-77. doi: 10.1111/imm.12548. Epub 2015 Dec 8.
PubMed PMID: 26489873; PubMed Central PMCID: PMC4717245.


Sridhar S, Brokstad KA, Cox RJ. Influenza Vaccination Strategies: Comparing
Inactivated and Live Attenuated Influenza Vaccines. Vaccines (Basel). 2015 Apr
24;3(2):373-89. doi: 10.3390/vaccines3020373. Review. PubMed PMID: 26343192;
PubMed Central PMCID: PMC4494344.


Panapasa JA, Cox RJ, Mohn KG, Aqrawi LA, Brokstad KA. The expression of B & T
cell activation markers in children's tonsils following live attenuated influenza
vaccine. Hum Vaccin Immunother. 2015;11(7):1663-72. doi:
10.1080/21645515.2015.1032486. PubMed PMID: 26148331; PubMed Central PMCID:
PMC4514187.


Cox RJ, Major D, Pedersen G, Pathirana RD, Hoschler K, Guilfoyle K, Roseby S,
Bredholt G, Assmus J, Breakwell L, Campitelli L, Sjursen H. Matrix M H5N1 Vaccine
Induces Cross-H5 Clade Humoral Immune Responses in a Randomized Clinical Trial
and Provides Protection from Highly Pathogenic Influenza Challenge in Ferrets.
PLoS One. 2015 Jul 6;10(7):e0131652. doi: 10.1371/journal.pone.0131652.
eCollection 2015. PubMed PMID: 26147369; PubMed Central PMCID: PMC4493055.


Eidem S, Tete SM, Jul-Larsen Å, Hoschler K, Montomoli E, Brokstad KA, Cox RJ.
Persistence and avidity maturation of antibodies to A(H1N1)pdm09 in healthcare
workers following repeated annual vaccinations. Vaccine. 2015 Aug
7;33(33):4146-54. doi: 10.1016/j.vaccine.2015.05.081. Epub 2015 Jun 7. PubMed
PMID: 26057137.


Lartey S, Pathirana RD, Zhou F, Jul-Larsen Å, Montomoli E, Wood J, Cox RJ.
Single dose vaccination of the ASO3-adjuvanted A(H1N1)pdm09 monovalent vaccine in
health care workers elicits homologous and cross-reactive cellular and humoral
responses to H1N1 strains. Hum Vaccin Immunother. 2015;11(7):1654-62. doi:
10.1080/21645515.2015.1048939. PubMed PMID: 26009966; PubMed Central PMCID:
PMC4514283.


Trombetta CM, Perini D, Vitale L, Cox RJ, Stanzani V, Piccirella S, Montomoli
E. Validation of Single Radial Haemolysis assay: A reliable method to measure
antibodies against influenza viruses. J Immunol Methods. 2015 Jul;422:95-101.
doi: 10.1016/j.jim.2015.04.009. Epub 2015 Apr 22. PubMed PMID: 25910832.


Wohlbold TJ, Nachbagauer R, Xu H, Tan GS, Hirsh A, Brokstad KA, Cox RJ,
Palese P, Krammer F. Vaccination with adjuvanted recombinant neuraminidase
induces broad heterologous, but not heterosubtypic, cross-protection against
influenza virus infection in mice. MBio. 2015 Mar 10;6(2):e02556. doi:
10.1128/mBio.02556-14. PubMed PMID: 25759506; PubMed Central PMCID: PMC4453582.


Trondsen M, Aqrawi LA, Zhou F, Pedersen G, Trieu MC, Zhou P, Cox RJ.
Induction of Local Secretory IgA and Multifunctional CD4⁺ T-helper Cells
Following Intranasal Immunization with a H5N1 Whole Inactivated Influenza Virus
Vaccine in BALB/c Mice. Scand J Immunol. 2015 May;81(5):305-17. doi:
10.1111/sji.12288. PubMed PMID: 25737202.